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Product Profile

Product Name	Anti-BRG1 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	SMARCA4
Gene Synonyms	BRG1 CSS4 SNF2 SWI2 MRD16 RTPS2 BAF190 SNF2L4 SNF2LB hSNF2b BAF190A SNF2-beta Hide
Gene Full Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gene Summary	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. Hide
Molecular Weight(MW)	185 kDa
Cellular Localizatio	Nucleus

Application

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WB

Western blot analysis using BRG1 antibody against Jurkat(1), COS7(2) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using BRG1 antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.