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Product Profile

Product Name	Anti-Parkin antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	PRKN
Gene Synonyms	HSPA8 HSP7C LAP1 HSC54 HSC70 HSC71 HSP71 HSP73 LAP-1 NIP71 HEL-33 HSPA10 HEL-S-72p Hide
Gene Full Name	parkin RBR E3 ubiquitin protein ligase
Gene Summary	The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] Hide
Molecular Weight(MW)	52 kDa
Source	Rabbit
Cellular Localizatio	Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus

Application

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WB

Western blot analysis using Parkin antibody against PANC-1 (1),MCF-7 (2), COS-7 (3) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded pancreatic tissues using Parkin antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of Hela cells using Parkin antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.