|
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
·
ICC/IF
Immunofluorescence
analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-Smad4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
SMAD4
Gene Synonyms
JIP
Hide
Gene Full Name
SMAD family member 4
Gene Summary
This gene encodes a member of the Smad
family of signal transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in response to
transforming growth factor (TGF)-beta signaling. The product of this gene
forms homomeric complexes and heteromeric complexes with other activated Smad
proteins, which then accumulate in the nucleus and regulate the transcription
of target genes. This protein binds to DNA and recognizes an 8-bp palindromic
sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts
as a tumor suppressor and inhibits epithelial cell proliferation. It may also
have an inhibitory effect on tumors by reducing angiogenesis and increasng blood
vessel hyperpermeability. The encoded protein is a crucial component of the
bone morphogenetic protein signaling pathway. The Smad proteins are subject
to complex regulation by post-translational modifications. Mutations or
deletions in this gene have been shown to result in pancreatic cancer,
juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia
syndrome. [provided by RefSeq, Aug 2017]
Hide
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
DPC4
MADH4
MYHRS
·
ICC/IF
Immunofluorescence analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
·
ICC/IF
Immunofluorescence analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
ICC/IF:1:100-1:500 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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