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    Anti-SREBP1 antibody
    • 品牌:OminimAbs
    • 产地:上海
    • 型号:毫升
    • 货号:OM641708
    • 发布日期: 2024-08-15
    • 更新日期: 2024-10-09
    产品详请
    产地 上海
    品牌 OminimAbs
    保存条件
    货号 OM641708
    用途 实验研究
    应用范围 科研实验
    抗原来源 电询
    保质期 2年
    抗体名 电询
    是否单克隆
    克隆性
    靶点 电询
    适应物种 电询
    形态 电询
    宿主 电询
    标记物 电询
    包装规格 毫升
    亚型 电询
    标识物 电询
    浓度 电询%
    免疫原 电询
    是否进口

    Product Profile

    Product Name

    Anti-SREBP1 antibody

    Antibody Type

    Primary Antibodies

    Immunogen

    Polypeptide

    Key Feature

    Clonality

    Polyclonal

    Isotype

    IgG

    Host Species

    Rabbit

    Tested Application

    ELISAIHCWB

    IHC:1:50~1:200
    WB:1:500~1:2000
    Notes:Optimal dilutions/concentrations should be determined by the researcher.

    Species Reactivity

    HumanMouseRat

    Concentration

    1 mg/ml

    Purification

    Protein A

    Target Information

    Gene Symbol

    SREBF1

    Gene Synonyms

    HMD
    IFAP2
    SREBP1
    bHLHd1

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    Gene Full Name

    sterol regulatory element binding transcription factor 1

    Gene Summary

    This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]

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    Molecular Weight(MW)

    122 kDa

    Source

    Rabbit

    Cellular Localizatio

    Nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane.

    Application

    ·        

    WB

    Western blot analysis using SREBP1 antibody against NIH3T3 (1), Jurkat (2) cell lysate.

    ·        

    IHC

    Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using SREBP1 antibody with DAB staining.

    Positive Control

    WB::1:200-1:2000||IHC::1:200-1:1000

    Application Notes

    IHC:1:50~1:200
    WB:1:500~1:2000
    Notes:Optimal dilutions/concentrations should be determined by the researcher.

    Additional Information

    Form

    Liquid

    Storage Instruction

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

    Storage Buffer

    Purified antibody in PBS with 0.05% sodium azide.


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