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Product Name

Anti-c-MYC antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Application

ELISAIHCWB

WB:1:200-1:2000
IHC:1:200-1:1000

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Protein A

Gene Symbol

MYC

Gene Synonyms

MRTL
MYCC
c-Myc
bHLHe39

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Gene Full Name

MYC proto-oncogene, bHLH transcription factor

Gene Summary

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

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Molecular Weight(MW)

49 kDa

Source

Rabbit

Cellular Localizatio

Nucleus

Application Notes

WB:1:200-1:2000
IHC:1:200-1:1000

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azi.